Non- Invasive Prenatal Screening- NIPS

Non-invasive Prenatal Screening
A Safe Kind Of Blood Test To Know Your Baby's Health
NIPS (Non-Invasive Prenatal Screening) is one of the new prenatal screening tests that check for common genetic conditions that can affect the health and development of the unborn child.
Testing Procedure
Take A Blood Sample
Take a blood sample from the pregnant woman from the 10th week of pregnancy
Analyze by using new generation sequencing technique at international prestigious laboratories
Result Interpretation
Send results to the prescribing doctor and conduct genetic counseling and follow-up treatment within 7-10 days*
Learn More About Non-Invasive Prenatal Screening (NIPS)

Non-Invasive prenatal screening (NIPS) is a method to help identify early abnormalities in the fetus. NIPS is highly appreciated for its accuracy, and safety for both mother and fetus. However, the NIPS test is still quite new in Vietnam, so many pregnant women do not understand this screening clearly.

Please refer to our following article if you have a need for this service!

NIPS (Non-Invasive Prenatal Screening) is a test that helps screen for chromosomal mutations that affect the health of the fetus.
The NIPS test helps to reduce the number of pregnant women who must undergo traditional diagnostic methods such as amniocentesis and chorionic villus sampling with many risks. NIPS ensure the absolute safety for mother and fetus, with an accuracy of up to 99.98%.

Because it is a screening method based on fetal DNA in mother’s blood. The test will investigate abnormalities on 23 pairs of fetal chromosomes. Therefore, NIPS is used to screen for chromosomal abnormalities:

  • Chromosome 21 (DOWN syndrome): This syndrome is caused by an extra copy of chromosome 21 in the gene. This is the most common genetic disease in infants. Children with Down have a flat nose, slanted eyes, short and small head, round shoulders, small ears, poor receptivity, have trouble in social integration, often suffer from cardiovascular diseases, etc.
    Chromosome 18 (Edward Syndrome): Children with Edwards syndrome usually have a life expectancy of less than 1 year. Common features of this syndrome are growth retardation, hypertonia, abnormalities of the hands or feet, heart defects and other organs, and severe intellectual disability.
    Chromosome 13 (Patau Syndrome): Life expectancy of affected children is usually less than 1 year. Children infected with this syndrome will have abnormalities of the heart, brain, and kidneys; cleft lip and cleft palate; severe intellectual disability.
  • Detected 5 deletions, including: deletion 1p36; DiGeorge (deletion 22q11.2); Angelman/Prader-Willi syndrome mutation (deletion of 15q11.2); Cri du Chat syndrome (due to missing segment 5p15.2); Wolf-Hirschhorn syndrome (due to deletion 4p16.3)
  • Ditected 4 diseases related to sex chromosomes.

The implementation of NIPS non-invasive prenatal screening test will bring many outstanding advantages as follows:

  • This is the most advanced method to detect early abnormalities in the unborn child from the 10th week to have a timely treatment plan.
  • It is absolutely safe for the fetus
  • The technique is simple by taking 7-10ml of maternal blood and conducting test without the need for invasive procedures such as amniocentesis or chorionic villus sampling.
  • With high diagnostic value, help to detect aneuploidy abnormalities, the false-positive rate is very low.
  • All pregnant women can use NIPS as their first line of screening for aneuploidy.
  • Quick response time, about 1 week.
  • This test can be done for both twins, singletons, artificial insemination, egg donation, surrogacy.

As soon as the pregnant mother enters the 10th week of pregnancy, this test can be performed to early detect possible abnormalities in the fetus.

The test is recommended for all pregnant women during pregnancy. As doctors’ recommendations, NIPS should be done in the following specific cases:

  • Older women (>35 years old), because older women often have a higher risk of having a baby with a birth defects.
  • Pregnant women with Double test or Triple test results belong to high and medium risk groups with aneuploidy.
  • Pregnant women have history of giving birth to children with birth defects
  • Pregnant women have a family history of genetic diseases
  • Pregnant women with a history of genetic diseases, working or living in an environment with radiation and toxic chemicals.

Compared with the double test and triple test, the NIPS test is rated higher by:

NIPS (non-invasive prenatal screening) test


Perform early screening from the 10th week onwards.

  • Non-invasive screening, simple blood test
    Fetal DNA test, highly accurate results.
    Low false positive rate (reduce the chance of unnecessary amniocentesis)
  • Screening all fetal chromosomes, helping to check for microsomal mutations


  • This is a relatively new test
  • The cost is quite high for each test
  • The test may not be able to analyze the sample and must be taken again, because the amount of fetal DNA in the mother’s blood is insufficient or the mother’s blood is hemolytic.

XN double test and triple test


Perform early screening between 11 and 13 weeks.

  • Non-invasive screening, simple blood test
  • Biochemistry test from mother’s blood (may be affected by eating and living causes)
  • Low cost of testing
  • Accepted as a standard antenatal care procedure in Vietnam


  • High false positive rate

Testable mainly for Down syndrome.

Non-invasive prenatal screening test from the 10th week of pregnancy.

Test results will be released quickly from 7-10 working days.

Negative result

A negative result means that the risk of trisomy 13, 18, and 21, and sex chromosome aneuploidy of the fetus is very low. Hence, pregnant women can rest assured to take care of their pregnancy according to the doctor’s instructions.

Positive result

A positive result means that the fetus is at high risk of being chromosome aneuploidy. To confirm this result, the doctor will have to carry out amniocentesis or take chorionic villus sampling. This gives the final diagnosis so that the doctor can recommend relevant methods later.

The NIPS test is far effective than other methods in the field of identifying many fetal malformations. Many pregnant women want to use this test but do not know where to get the best and safest NIPS prenatal screening. To perform this test, pregnant women need to be truly careful to choose reputable sites like CHEK Genomics.

CHEK Genomics is a leading unit in Vietnam in the field of gene decoding and genetics. CHEK Genomics always updates the latest, most modern and advanced gene sequencing technology.

Along with that, we own a team of leading experts in the fields of medicine, technology and genetics, ensuring the best service quality with the most accurate results.

In addition, CHEK Genomics offers NIPS package at a reasonable cost. The testing process here is extremely simple, professional, and fast, returning the fastest results to customers.

For more information about the service, please contact CHEK Genomics immediately with the following information:

  • Unit 216, Harbor View Tower, 35 Nguyen Hue, Ben Nghe Ward, District 1, City. HCM.
  • Phone number: 091 176 3082.

Noninvasive prenatal screening (NIPS) is a test that detects abnormal chromosome. During the test, the doctor will detect the presence of a boy chromosome (Y) or a girl chromosome (X).

Therefore, NIPS results may reveal the sex of the fetus. However, Vietnamese law prohibits the disclosure of fetal gender in any form, CHEK Genomics will not report fetal gender in NIPS results.

There will be a small percentage of NIPS test that fail to provide results, due to reasons such as low fetal fraction, maternal malignancy or pregnant women are being treated for hemophilia.

However, this rate is extremely low, pregnant women do not worry too much when performing NIPS. Because this is a test method that gives results with high accuracy and information early in pregnancy.

NIPS is a non-invasive prenatal test that provides a lot of information about fetal health from the early stages and almost labs can not report the results of twins.

However, the NIPS test at CHEK Genomics only reports for one or both babies with the disease, but it cannot accurately show the specific one getting the disease. To get the final diagnosis, the doctor will conduct methods such as amniocentesis and chorionic villus sampling.

All of our above information has helped pregnant women understand more about the non-invasive prenatal screening service- NIPS. For more advice and quotes on services, please contact CHEK Genomics via hotline 091 176 3082 for the fastest support from our staff.